TARGET AUDIENCE
This educational activity is intended for members of hematology care teams, including physicians, nurse practitioners, and PAs.

PROGRAM OVERVIEW
This is a recording of a live satellite symposium that took place at the 2025 ISTH Congress in Washington, DC. This session was designed for clinicians eager to stay informed as the hemophilia toolbox continues to expand. This recording will deepen your understanding of how the different therapies work in order to individualize treatment. Led by top experts in the field, the session featured the latest in clinical trial data, engaging discussions, and proven best practices for managing patients with hemophilia A. Don’t miss this opportunity to sharpen your skills, elevate your practice, and engage directly with leading voices in hemophilia care.

Upon completion of this activity, the learners should be able to:

• Explain the biological and therapeutic mechanisms by which FVllla mimetics function in the management of hemophilia A
• Describe the differences between the currently approved FVllla mimetic and the next-generation agents presently under clinical development
• Outline current research results for approved and emerging FVllla mimetics

Cihan Ay, MD
Internal Medicine and Haematology
Medical University of Vienna
Vienna, Austria

Carmen Escuriola-Ettingshausen, MD
Director of the Haemophilia Centre Rhein Main-HZRM
Pediatrics and Haematology
Centre Rhein Main-HZRM
Frankfurt-Mörfelden, Germany

Cedric Hermans, MD, PhD, FRCP
Head of Division
Adult Haematology and The Haemostasis and Thrombosis Unit
Cliniques Universitaires Saint-Luc
Full Professor, Medical School
Catholic University of Louvain (UCLouvain)
Brussels, Belgium

In support of improving patient care, this activity has been planned and implemented by The France Foundation and International Society on Thrombosis and Haemostasis. The France Foundation is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the health care team.

Physician Credit Designation: The France Foundation designates this live activity for a maximum of 1.25 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

All other health care professionals completing this course will be issued a statement of participation.

DISCLOSURE POLICY
In accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education, The France Foundation (TFF) and the ISTH require that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial entity. TFF and the ISTH resolve all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all their educational programs.

Furthermore, TFF and the ISTH seek to verify that all scientific research referred to, reported, or used in a CME/CE activity conforms to the generally accepted standards of experimental design, data collection, and analysis. TFF and the ISTH are committed to providing learners with high-quality CME/CE activities that promote improvements in health care and not those of a commercial interest.

Planning committee members, faculty, reviewers, and activity staff have disclosed the following relevant financial relationships. All relevant financial relationships listed have been mitigated.

TFF and the ISTH require CME faculty (speakers) to disclose when products or procedures being discussed are off label, unlabeled, experimental and/or investigational, and any limitations on the information that is presented, such as data that are preliminary, or that represent ongoing research, interim analyses, and/or unsupported opinion. Faculty in this activity may discuss information about pharmaceutical agents that are outside of US Food and Drug Administration approved labeling.

This information is intended solely for continuing medical education and is not intended to promote off-label use of these medications. TFF and the ISTH do not recommend the use of any agent outside of the labeled indications. If you have questions, contact the Medical Affairs Department of the manufacturer for the most recent prescribing information.

This activity is supported by independent medical educational grants from Novo Nordisk and Roche.

The France Foundation and the ISTH present this information for educational purposes only. The content is provided solely by faculty who have been selected because of recognized expertise in their field. Participants have the professional responsibility to ensure that products are prescribed and used appropriately on the basis of their own clinical judgment and accepted standards of care. The France Foundation, the ISTH, and the commercial supporter(s) assume no liability for the information herein.

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