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CME Information
Accreditation Statements This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the American Osteopathic Association (AOA) and The France Foundation (TFF).
The American College of Osteopathic Internists (ACOI) is accredited by the American Osteopathic Association to provide osteopathic continuing medical education for physicians.
Credit Designations The American Osteopathic Association (AOA) designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
The American College of Osteopathic Internists (ACOI) designates this activity for a maximum of 1.5 AOA Category 1-B Credits and will report CME and specialty credits commensurate with the extent of the physician’s participation in this activity.
Learning Objectives After completing this activity, learners will be able to:
Recognize the increased risks of first trimester pregnancy loss and congenital malformations associated with mycophenolate use
Explain the risks of mycophenolate exposure during pregnancy to patients
Demonstrate effective patient education on pregnancy prevention, including appropriate contraceptive methods during treatment
Identify alternative immunosuppressive therapies with lower embryofetal risk for use in pregnancy or preconception planning
Describe the process for reporting pregnancies to the Mycophenolate Pregnancy Registry per REMS requirements
Review approaches to encourage patient participation in the registry to contribute to safety monitoring and research
Faculty
Corinna Muller, DO, FACOOG (dist.), MBA
Emmie Strassberg, DO, FACOOG (dist.)
Planners
Margaret Das, PhD
Heather Tarbox, MPH
Emily Peck
Heather Jastremski, MPH
Darcy Steinberg
Release date: 11/24/25 Expiration date: 11/23/26 Estimated time to complete activity: 1.5 hours
Statement of Need/Description/Summary of Gap Analysis There is a critical and well-documented gap in clinician awareness and patient counseling regarding the embryofetal toxicity risks associated with mycophenolate use during pregnancy. Despite established evidence linking prenatal exposure to significantly increased risks of first-trimester pregnancy loss and congenital malformations, current clinical practices often lack consistent implementation of risk mitigation strategies. This gap compromises patient safety, particularly among reproductive-age individuals who may not receive adequate counseling on pregnancy prevention or informed decision-making prior to initiating therapy. This interactive, case-based activity will target awareness, counseling protocols, and risk mitigation.
Target Audience This activity is for osteopathic physicians and other health care professionals, including primary care/family medicine physicians, physician associates (PAs), nurse practitioners (NPs), and other specialties, including OB/GYN, nephrology, etc., who prescribe and/or participate in the treatment of patients taking mycophenolate products.
Instructional Format Online interactive case-based activity including an expert panel video series
Method of Participation There are no fees for participating in this CME activity. To participate in the activity, physicians will be required to take the following steps:
Read the learning objectives and faculty disclosures
Complete the pre-test
Participate in the activity
Complete the post-test and activity evaluation
Participants who successfully complete the evaluation and the post-test (scoring 70% or higher in a maximum of three attempts) will receive 1.5 AOA Category 1-B Credits or 1.5 AMA PRA Category 1 Credits™.
Disclosures The American Osteopathic Association has implemented a policy to comply with the current Accreditation Council for Continuing Medical Education (ACCME) Standards for Integrity and Independence in Accredited Continuing Education requiring mitigation of all conflicts of interest. Faculty declaring a relevant commercial interest must be identified in the activity syllabus and/or program.
In accordance with disclosure policies of AOA and ACCME, every effort has been made to ensure all CME activities are balanced, independent, objective, and scientifically rigorous. These policies include complying with ACCME’s Standards for Integrity and Independence in Accredited Continuing Education and mitigating all relevant conflicts of interest for all individuals in control of content.
The following faculty, presenters, and planning committee members have indicated that they have no relationship(s) that could be perceived as a potential conflict of interest. Name of Faculty or Presenter Role(s) Reported Financial Relationship (Name of Commercial Interest and Nature of Relationship) Margaret Das, PhD Medical content writer No relevant financial disclosures Heather Tarbox, MPH TFF staff No relevant financial disclosures Emily Peck TFF staff No relevant financial disclosures Heather Jastremski, MPH AOA staff No relevant financial disclosures Darcy Steinberg AOA staff No relevant financial disclosures
The following faculty, presenters, and planning committee members have indicated that they have a relevant relationship(s) that could be perceived as a potential conflict of interest. All of the relevant financial relationships listed for these individuals have been mitigated. Name of Faculty or Presenter Role(s) Reported Financial Relationship Corinna Muller, DO Steering committee member No relevant financial disclosures Emmie Strassberg, DO Steering committee member No relevant financial disclosures
Disclaimer The information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient's medical condition. The viewpoints expressed in this CME activity are those of the authors/faculty. They do not represent an endorsement by the AOA. In no event will the AOA be liable for any decision made or action taken in reliance upon the information provided through this CME activity.
Commercial Support This activity is supported by an independent medical educational grant from the REMS Program Companies (RPC).
